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This compound was created to preferentially activate G-protein signaling pathways whilst reducing β-arrestin recruitment, a characteristic that implies a potential for lessened side effects commonly connected with opioid use, such as respiratory melancholy and tolerance improvement
This unique binding method underpins its purposeful selectivity, as interactions with TM6/seven are crucial for β-arrestin activation .
Q. How can researchers resolve contradictions With this compound's β-arrestin recruitment information across experimental disorders?
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Standardize Agonist Exposure Situations : this compound’s sluggish dissociation kinetics involve extended observation intervals to seize entire β-arrestin recruitment .
This compound is actually a research compound and is intended for review in specially Outfitted laboratories.
SR-17018 is intended only as a compound for scientific and research needs in Specific laboratory situations in compliance with all requirements and protection actions.
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